李庆超

邮箱：liqingchao@sdnu.edu.cn

办公地址：长清校区博物楼531房间

办公电话：0531-86182518

工作经历：

2018-09 至 英国上市公司365，英国上市365，讲师

2018-09 至 2020-09，英国上市公司365，博士后

2013-07 至 2014-07，齐鲁干细胞工程有限公司，研发部，实验员

2010-07 至 2013-07，中国科学院上海巴斯德研究所，病毒性肝炎组，助理研究员

学习经历：

2014-09 至 2017-12，中国科学院大学，微生物学，博士

2007-09 至 2010-07，中国农业科学院研究生院，预防兽医学，硕士

2003-09 至 2007-07，英国上市公司365，生物技术，学士

研究方向：中心体，纤毛及相关疾病

研究工作：

本研究团队聚焦于纤毛发生的分子调控机制；动纤毛的结构与功能解析；动纤毛及精子鞭毛运动性及相关疾病的遗传与病理基础。

承担项目：

ALG-2调控纤毛发生的分子机制研究，国家自然科学基金青年基金，2020年01月至2022年12月，直接费用：25万，主持人。

精子发生过程中精子领协同鞭毛组装的分子机制，山东省自然科学基金面上项目, 2025年1月至2027年12月， 直接费用：10万，主持人。

代表论著：

1. Lyu Q. ^*, Li Q. *, Li J. *, Luo J., Liu C., Nai S., Liu H., Zhu X., Song T. #, Liu M. #, and Zhao H. # (2026). Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia. eLife, 15: RP110601. doi: 10.7554/eLife.110601.1.

2. Li Q. *, Zi X. *, Lu Y., Yin H., Lyu Q., Han J., Shen H., Meng X., Nai S., Zhou J. #, Zhao H. #, and Song T. # (2026). Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice. J Mol Cell Biol, (Accepted).

3. Chen Q. *, Ma S. *, Liu H. *, Liu J., Li Q., Lyu Q., Yin H., Zhao J., Nai S., Song T., Liu H., Zhou J., Yan X., Zhu X. #, and Zhao H. # (2025). JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution. EMBO Rep, 10. doi: 10.1038/s44319-025-00671-7.

4. Lyu Q., Wang Y., Zhou J., Zhao H. #, Zhong T. #, and Li Q. # (2025). Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation. J Mol Cell Biol, 10: mjaf054. doi: 10.1093/jmcb/mjaf054.

5. Song T. *, Li Q. *, Lyu Q.*, Zhao J. *, Zi X., Ma S., Luo J., Li S., Nai S., Liu H., Zhu X., Li T., Zhou J. #, and Zhao H. # (2025). EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility. Proc Natl Acad Sci USA, 122 (41): e2510243122. doi: 10.1073/pnas.2510243122.

6. Lu Y. *, Zi X. *, Lyu Q. *, Li Q., Yin H., Wang Y., Chen Q., Kang B., Nai S., Zhou J., Zhao H. #, and Song T. # (2025). Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice. J Mol Cell Biol, 17(5): mjaf022. doi: 10.1093/jmcb/mjaf022.

7. Wang D., Li Q., Yu Z., Zhao J., Hu M., Geng S., Liu X., Zhao S., Song T., Liu M., Li D., Zhao H. #, and Zhou J. # (2025). FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis. J Cell Biol, 224(10): e202412224. doi: 10.1083/jcb.202412224.

8. Song D. *, Li Q. *, Sun Y. *, Zhao H. #, and Song T. # (2025). The cilia-associated protein CCDC89 is dispensable for male fertility in mice. Cytoskeleton (Hoboken). doi: 10.1002/cm.70057.

9. Song T. *, Zhou P. *, Zhang F. *, Liu C. *, Han X., Yue Y., Hu M., Yan S., Li Q., Liu M., Zhou J. #, and Zhao H. # (2025). USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation. J Genet Genomics, 53(2): 256-268. doi: 10.1016/j.jgg.2025.06.006.

10. Zi, X.*., Li, Q.*., Lu, Y., Lyu, Q., Guo, H., Meng, X., Zhou, J., and Zhao, H#. CCDC181 is required for proper spermiogenesis in mice. J. Genet. Genom. 51, 1327–1330 (2024).

11. Zhu, Y., and Li, Q#. Multifaceted roles of PDCD6 both within and outside the cell. J. Cell. Physiol (2024).

12. Li, Q.*, Pan, W., Zhou, J., Yu, H., and Xie, S. # Targeting protein aggregation for the treatment of neurodegenerative diseases. Med. Plus 1, 100005 (2024).

13. Lyu, Q. *, Li, Q.*, Zhou, J. & Zhao, H#. Formation and function of multiciliated cells. J. Cell Biol. 223, e202307150 (2023).

14. Nie, H.*, Li, Q.* & Pan, W.# The emerging roles of protein arginine methyltransferases in antiviral innate immune signaling pathways. Front. Microbiol. 14, 1322929 (2023).

15. Zhao, H.*#, Li, Q. & Zhou, J#. Ciliary ectosomes: critical microvesicle packets transmitted from the cell tower. Sci. Bull. (2023) doi:10.1016/j.scib.2023.09.027.

16. Ran, J., Zhang, Y., Zhang, S., Li, H., Zhang, L., Li, Q., Qin, J., Li, D., Sun, L., Xie, S., et al. (2022). Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity. Adv. Sci. 9, e2105365. 10.1002/advs.202105365.

17. Tong, Y., Li, Q., Li, R., Xu, Y., Pan, Y., Niu, J., and Zhong, J. (2020). A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution. J Virol 94. 10.1128/jvi.00622-20.

18. He, X., Zhang, Y., Yang, L., Feng, J., Yang, S., Li, T., Zhong, T., Li, Q., Xie, W., Liu, M., et al. (2020). BAG6 is a novel microtubule-binding protein that regulates ciliogenesis by modulating the cell cycle and interacting with γ-tubulin. Exp. Cell Res. 387, 111776. 10.1016/j.yexcr.2019.111776.

19. Zhang, Z., Li, Q., Du, X., and Liu, M. (2020). Application of electrochemical biosensors in tumor cell detection. Thorac. Cancer 11, 840–850. 10.1111/1759-7714.13353.

20. Tong, Y., Lavillette, D., Li, Q. & Zhong, J. Role of Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly. Frontiers in Immunology 9, 285 (2018).

21. Jie Lu, Yu Xiang, Wanyin Tao, Qingchao Li, Na Wang, Yongfeng Gao, Xiaogang Xiang, Qing Xie, Jin Zhong. A novel strategy to develop a robust infectious hepatitis C virus cell culture system directly from a clinical isolate. Journal of Virology. 2014;88(3):1484-1491. doi:10.1128/JVI.02929-13.

22. Miao, L., Liu, Y., Li, Q., Wang, Z., Li, H., and Zhang, G. (2010). Screening and sequence analysis of the hemolysin gene of Fusobacterium necrophorum. Anaerobe 16, 402–404. 10.1016/j.anaerobe.2010.04.005.

23. 李庆超, 钟劲. 分子生物学技术推进丙型肝炎病毒的发现和研究—2020年诺贝尔生理学或医学奖解读, 自然杂志[J], 2020, 42(6) :449-455.

24. 谢磊, 郝沛, 吴瑞红, 李庆超, 牛俊奇, 钟劲临床肝胆病杂志[J], 2018, 34(9) :449-455.1884-1990.

25. 李庆超，苗利光，等.牛病毒性腹泻病毒研究进展[J].动物医学进展. 2009, 30(5): 68~72.

26. 李庆超, 苗利光, 等.牛病毒性腹泻病毒反转录及3'-末端克隆测序方法研究[J].特产研究, 2010,32(2):12-15.

27. 李庆超, 苗利光, 等.中国牛病毒性腹泻病毒JZ05-1分离株全基因测序及分析[J].病毒学报, 2010, 26(03): 238-243