个人简介

谭彦杰，女，中共党员，副教授，硕士生导师。2020年毕业于华中农业大学，获博士学位，同年加入英国上市公司365。先后主持国家自然科学基金及山东省自然科学基金等多项课题。以第一作者或通讯作者在Nature Communications，EMBO Reports，Acta Pharmacologica Sinica等国际主流期刊发表学术论文10余篇。在教学中承担本科生《动物学实验》及博士研究生《生物标本制作技术》等课程。担任Nature Communications，Cell Death & Disease， Journal of Cellular Physiology， Cell death discovery 等审稿专家。

邮箱：620036@sdnu.edu.cn

研究方向

致力于探究细胞器交互网络在代谢稳态调控中的核心作用，重点关注脂滴(Lipid Droplet)与纤毛(Cilium)这两种动态细胞器间的功能对话(Crosstalk)。我的研究旨在阐明它们如何作为整合营养状态、能量感知与信号转导的协同单元，在肥胖、非酒精性脂肪肝(NAFLD)等脂质代谢紊乱疾病的发生发展中扮演关键角色。

承担项目

1. 国家自然科学基金青年基金项目，2025.01-2027.12，在研，主持；

2. 山东省自然科学基金面上项目，2025.07-2028.06，在研，主持；

3. 山东省自然科学基金青年项目，2024.01-2026.12，在研，主持。

代表性论文

1. Yanjie Tan, Zhenzhou Huang, Yi Jin, Jiaying Wang, Hongjun Fan, Yangyang Liu, Liang Zhang, Yue Wu, Peiwei Liu, Tianliang Li, Jie Ran, He Tian, Sin Man Lam, Min Liu, Jun Zhou*, Yunfan Yang*. Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice. Nature Communications. 2024 Sep 27;15(1):8273.

2. Renjie Hong^#, Yanjie Tan^#, Xiaoyu Tian^#, Zhenzhou Huang, Jiaying Wang, Hua Ni, Jia Yang, Weiwen Bu, Song Yang, Te Li, Fan Yu, Weilong Zhong, Tao Sun, Xiaohong Wan, Dengwen Li, Min Liu, Yunfan Yang*, Jun Zhou*. XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis. EMBO Reports. 2024 Mar;25(3):1055-1074.

3. YanJie Tan, Yi Jin, Jun Zhou*, YunFan Yang*. Lipid droplets in pathogen infection and host immunity. Acta Pharmacologica Sinica. 2024 Mar;45(3):449-464.

4. Yanjie Tan, Yi Jin, Pengxiang Zhao, Jian Wu, Zhuqing Ren*. Lipid droplets contribute to myogenic differentiation in C2C12 by promoting the remodeling of the actin filament. Cell Death&Disease. 2021 Nov 23;12(12):1102.

5. Yanjie Tan, Jing Zhang, Yi Jin*. Nonsense-mediated mRNA decay suppresses injury-induced muscle regeneration via inhibiting MyoD transcriptional activity. Journal of Cellular Physiology. 2023 Nov;238(11):2638-2650.

6. Renjie Hong, Xiaoyu Tian, Hongbo Ma, Hua Ni, Jia Yang, Weiwen Bu, Te Li, Song Yang, Dengwen Li, Min Liu, Yanjie Tan*. Primary cilium-mediated signaling cascade suppresses age-related biliary fibrosis. Journal of Cellular Physiology. 2023 Nov;238(11):2600-2611.

7. Hongjun Fan, Yanjie Tan*. Lipid Droplet-Mitochondria Contacts in Health and Disease. International Journal of Molecular Sciences.

8. Zhenzhou Huang, Yanjie Tan*. The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive. International Journal of Molecular Sciences.

9. Yanjie Tan, Yi Jin, Qian Wang, Jin Huang, Xiang Wu, Zhuqing Ren*. Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells. Cells, 2019 Oct 11;8(10):1241.

10. Yanjie Tan, Zhenfa Ma, Yi Jin, Ruojun Zong, Jian Wu, Zhuqing Ren*. MicroRNA 4651 regulates nonsense-mediated mRNA decay by targeting SMG9 mRNA. Gene. 2019 Jun 15:701:65-71.

11. Yanjie Tan, Yi Jin, Xiang Wu, Zhuqing Ren*. PSMD1 and PSMD2 Regulate HepG2 Cell Proliferation and Apoptosis via Modulating Cellular Lipid Droplet Metabolism. BMC molecular and cell biology. 2019 Nov 8;20(1):24.

12. Yanjie Tan, Yi Jin, Sheng Wang, Jianhua Cao, Zhuqing Ren*. The RNA Surveillance Factor UPF1 Regulates Migration and Adhesion of Porcine Skeletal Muscle Satellite Cells. Journal of Muscle Research and Cell Motility. 2021 Jun;42(2):203-217.

13. Zhenzhou Huang, Yishu Peng, Yuhui Wei, Yanjie Tan*. Nonsense-mediated mRNA decay promotes C2C12 cell proliferation by targeting PIK3R5. Journal of Muscle Research and Cell Motility. 2023 Mar;44(1):11-23.