陈颜，教授、博导、泰山学者青年专家

工作经历：

2021/12-至今英国上市365，教授

2018/10-2021/12暨南大学医学院，教授

2015/01-2018/10美国西南医学中心，博士后

教育经历：

2009/09-2014/12南开大学博士

2005/09-2009/06南开大学学士

研究内容：

肿瘤微环境是肿瘤细胞产生及赖以生存的环境，具有缺氧、偏酸性、营养匮乏与氧化应激等标志性特征。课题组致力于解析肿瘤微环境调控肿瘤发生发展的分子机制，为肿瘤治疗提供新的靶标、策略、技术及先导化合物，重点开展以下研究方向：

1. 低氧感知与应答：聚焦于PHD-VHL-HIF信号通路，揭示肿瘤细胞感知及应答低氧的分子机制 (Adv Sci, 2025; JBC, 2024; Cell Death Dis, 2024; Oncogene, 2023; JMC, 2023; JCP, 2022; Pharmocol Ther, 2022/2021; Cancer Res, 2020/2020; Cancer Lett, 2020; JCI, 2018)。

2. 代谢重编程：重点关注肿瘤细胞糖脂代谢重编程的分子机制，探索利用中间代谢产物治疗肿瘤的新策略 (Nat Commun, 2026; MedComm,2025; Cell Investigation, 2025; Sci Adv, 2022; Cancer Res, 2022; Cell Mol Life Sci, 2021)。

3. 氧化应激与DNA损伤修复：阐释PPP和KEAP1-NRF2信号通路通过调控ROS水平维持基因组稳定性的机制 (PNAS, 2024; Nat Commun, 2021; Neoplasia, 2021; Oncogene, 2020)。

发表论文：

1. Fei Meng^#, Yating Du^#, Junjie Liang^#, Huiyan Li, Jingjing Wang, Kexin Tang, Ruixue Kong, Huanran Sun, Tingting Yin, Junru Qin, Xiaomeng Yang, Changliang Shan, Min Liu, Guiwen Yang, Jichun Zhang, Yijie Wang^*, Jun Zhou^*, Yan Chen^*. The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis. Nat Commun. 2026 Jan 20;17(1):614.

2. Fei Meng^#, Huiyan Li^#, Yijie Wang^*, Zhiming Zheng^*, Yan Chen^*. The mechanism of AKT activation in cancer. Cell Investigation. 2025 Dec;1(4):100036.

3. Yating Du^#, Jingjing Wang^#, Min Wang^#, Yao Zhang^#, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang^*, Jun Zhou^*, Yan Chen^*. NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression. Adv Sci (Weinh). 2025 Nov;e13380.

4. Huiyan Li^#, Fei Meng^#, Junjie Liang^#, Yijie Wang^*, Changliang Shan^*, Yan Chen^*. UFMylation System: Biological Functions, Molecular Mechanisms, Diseases, and Drug Discovery. MedComm (2020). 2025 Oct;6(10):e70424.

5. Miaomiao Zheng, Shuo Wang, Kexin Tang, Ruixue Kong, Xuemeng Wang, Jun Zhou, Yan Chen^*, Yijie Wang^*. The CYLD–PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells. PNAS. 2025 Jan;122(1):e2413890121.

6. Kexin Tang^#, Tingting Yin^#, Bo Deng^#, Min Wang, Zixuan Ren, Shuo Wang, Xiong Liu, Huiyan Li, Jingjing Wang, Yating Du, Jun Zhou, Yan Chen^*, Yijie Wang^*. USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion. J Biol Chem. 2024 Aug 9:107672.

7. Shuo Wang, Huiyan Li, Xiong Liu, Tingting Yin, Tingru Li, Miaomiao Zheng, Min Liu, Xiaoqian Meng, Jun Zhou, Yijie Wang, Yan Chen^*. VHL suppresses UBE3B-mediated breast tumor growth and metastasis. Cell Death Dis. 2024 Jun 24;15(6):446.

8. Wang^#, Xiong Liu^#, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen^*. UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation. Oncogene. 2023 Nov;42(46):3394-3406.

9. Miao Chen^#, Ping Zhou^#, Yun Kong^#, Jingrui Li, Yan Li, Yao Zhang, Jie Ran, Jun Zhou, Yan Chen^*, Songbo Xie^*. Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC. J Med Chem. 2023 Jan;66(2):1339-1348.

10. Yijie Wang^#, Xiong Liu^#, Weixiao Huang^#, Junjie Liang^*, Yan Chen^*. The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment. Pharmacol Ther. 2022 Dec; 240:108303.

11. Wei Xie^#, Siqi Gao^#, Yunfan Yang^*, Hongjie Li, Junyan Zhou, Mingzhen Chen, Song Yang, Yijun Zhang, Liang Zhang, Xiaoqian Meng, Songbo Xie, Min Liu, Dengwen Li, Yan Chen, Jun Zhou^*. CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. Cell Rep. 2022 Dec 27;41(13):111864.

12. Maowu Luo, Lei Bao, Yan Chen, Yuanyuan Xue, Yong Wang, Bo Zhang, Chenliang Wang, Chase D Corley, Jeffrey G McDonald, Ashwani Kumar, Chao Xing, Yisheng Fang, Erik R Nelson, Jennifer E Wang, Yingfei Wang, Weibo Luo. ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Sci Adv. 2022 Jul 15;8(28):eabn5295.

13. Bo Zhang^#, Hui Peng^#, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo J Hatanpaa, John A Copland, Ralph J DeBerardinis, Yingfei Wang^*, Weibo Luo^*. Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma. Cancer Res. 2022 Jul 5;82(13):2388-2402.

14. Tangming Guan, Xiao Yang, Hui Liang, Jiayi Chen, Yan Chen^*, Yingjie Zhu^*, Tongzheng Liu^*. Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple‐negative breast cancer by stabilizing Snail1. J Cell Physiol. 2022 Jul;237(7):2992-3000.

15. Weixiao Huang^#, Xiong Liu^#, Yao Zhang^#, Guo Chen, Li Yu, Mingxia Deng, Guangqiang Li, Lai Jin, Tongzheng Liu^*, Yijie Wang^*, Yan Chen^*. USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF-2α. J Cell Physiol. 2022 Apr;237(4):2211-2219.

16. Ling Tian^#, Congcong Chen^#, Yanguan Guo^#, Fan Zhang^#, Jinye Mi, Qi Feng, Shengbin Lin, Naite Xi, Jiaxin Tian, Li Yu, Yan Chen, Mingrong Cao, Caiyong Lai^*, Jun Fan^*, Yongchang Zhang^*, Guo Chen^*. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. Neoplasia. 2021 Jul;23(7):643-652.

17. Yijie Wang^#, Guangqiang Li^#, Mingxia Deng, Xiong Liu, Weixiao Huang, Yao Zhang, Min Liu, Yan Chen. The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics. Pharmacol Ther. 2021 May; 221:107783.

18. Yijie Wang, Yan Chen, Chenliang Wang, Mingming Yang, Yanan Wang, Lei Bao, Jennifer E. Wang, Bongwoo Kim, Kara Chan, Weizhi Xu, Capota Emmanuela, Janice Ortega, Deepak Nijhawan, Guomin Li, Weibo Luo^*, Yingfei Wang^*. MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth. Nat Commun. 2021 May 19;12(1):2954.

19. Bo Zhang^#, Yan Chen^#, Xiaolei Shi, Mi Zhou, Lei Bao, Kimmo J Hatanpaa, Toral Patel, Ralph J DeBerardinis, Yingfei Wang, Weibo Luo. Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma. Cell Mol Life Sci. 2021 Jan;78(1):195-206.

20. Yan Chen, Min Liu, Yanling Niu, Yijie Wang. Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming. Cancer Lett. 2020 Dec; 495:211-223.

21. Zhen Shu^#, Zhen Li^#, Huanhuan Huang^#, Yan Chen, Jun Fan, Li Yu, Zhihui Wu, Ling Tian, Qi Qi, Shuang Peng, Changyong Wei, Zhongqiu Xie, Xiaobo Li, Qi Feng, Hao Sheng, Guangqiang Li, Dongping Wei, Changliang Shan, Guo Chen. Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition. Oncogene. 2020 Aug;39(35):5721-5733.

22. Yijie Wang^#, Yan Chen^#, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang^*, Weibo Luo^*. CHD4 is a coactivator of hypoxia-inducible factors that promotes breast cancer progression. Cancer Res. 2020 Sep 15;80(18):3880-3891.

23. Yanling Niu, Lei Bao, Yan Chen, Chenliang Wang, Maowu Luo, Bo Zhang, Mi Zhou, Jennifer E Wang, Yisheng V Fang, Ashwani Kumar, Chao Xing, Yingfei Wang^*, Weibo Luo^*. HIF2-induced long noncoding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis. Cancer Res. 2020 Mar 1;80(5):964-975.

24. Lei Bao, Yan Chen, Hsien-Tsung Lai, Shwu-Yuan Wu, Jennifer Wang, Kimmo J. Hatanpaa, Jack M. Raisanen, Miles Fontenot, Bradley Lega, Cheng-Ming Chiang, Gregg L. Semenza, Yingfei Wang^*, Weibo Luo^*. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591.

25. Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Ashwani Kumar, Jennifer E. Wang, Chenliang Wang, Xuan Zou, Chao Xing, Yingfei Wang^*, Weibo Luo^*. ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis. J Clin Invest. 2018 May 1;128(5):1937-1955.

26. Chaoyi Li^#, Lijuan Kan^#, Yan Chen^#, Xiudeng Zheng, Weini Li, Wenxin Zhang, Lei Cao, Xiaohui Lin, Shanming Ji, Shoujun Huang, Guoqiang Zhang, Xiaohui Liu, Yi Tao, Shian Wu^*, Dahua Chen^*. Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation. Cell Res. 2015 Oct;25(10):1152-70.

27. Biao Ma, Yan Chen, Ling Chen, Hongcheng Cheng, Chenglong Mu, Jie Li, Ruize Gao, Changqian Zhou, Lei Cao, Jinhua Liu, Yushan Zhu, Quan Chen^*, Shian Wu^*. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015 Jan;17(1):95-10

论著：

1. Drug Delivery to Tumors ─ Recent Strategies and Techniques, Springer Nature, 2025

2. 脑转移瘤基础与临床，上海科技出版社，2025

承担项目：

1. 国家自然科学基金面上项目，UFL1-AKT1正反馈环路调控脂质合成促进乳腺癌进展的分子机制研究，2026/1/1-2029/12/31，主持

2. 山东省自然科学基金面上项目，VHL通过降解UBE3B抑制乳腺癌的生长与转移，2024/1/1-2026/12/31，主持

3. 山东省泰山学者青年专家项目，2023/1/1-2025/12/31，主持

4. 广州市科技计划项目，低氧微环境下USP5促进乳腺癌生长与转移的分子机制研究，2021/4/1-2023/3/31，主持

5. 广东省自然科学基金面上项目，低氧微环境下RNA解旋酶DDX21调控乳腺癌生长与转移的分子机制研究，2021/1/1-2023/12/31，主持

6. 广东省自然科学基金面上项目，去泛素化酶USP7在三阴性乳腺癌中调控内质网应激的分子机制研究，2020/1/1-2022/12/31，主持

7. 国家自然科学基金青年项目，E3泛素连接酶UBE3B通过HIF-2α调控乳腺癌生长与转移的分子机制研究，2020/1/1-2022/12/31，主持

学术兼职：

中国细胞生物学学会肿瘤细胞生物学分会委员、中国抗癌协会肿瘤缺氧生物学和临床应用专委会委员、山东省细胞生物学学会理事、山东省生物化学与分子生物学学会理事

联系方式：

邮箱：yanchen@sdnu.edu.cn

地址：山东省济南市长清校区博物楼A座547室