赵惠杰
日期： 2022/03/24 作者： 浏览量：
姓名：赵惠杰
办公地址：长清校区博物楼531房间
办公电话：0531-86182518
工作经历：
2022.01- 至今 英国上市365 教授
2017.05-2021.12 美国国家卫生研究院肿瘤研究所 博士后
2014.01-2017.04 中国科学院上海生物化学与细胞生物研究所 博士后
学习经历：
2007.09-2013.12 中国科学院上海生物化学与细胞生物研究所 博士
2003.09-2007.07 南京大学英国上市365 学士
研究方向：中心体，纤毛及相关疾病
研究工作：
纤毛（cilia）是一种突出于细胞表面的毛发状细胞器，主要由基体（由中心体转化而来）、转接区、轴丝和纤毛膜等构成，其在信号传导、细胞运动以及维持组织稳态等多种生理活动中发挥重要功能。由于纤毛在多种生理活动中发挥重要作用，纤毛结构或功能的异常会导致多种人类遗传疾病，统称为纤毛病（ciliopathy）。本实验室综合运用分子生物学、细胞生物学和发育生物学等技术和手段，以细胞、斑马鱼、小鼠等系统深入探讨中心体和纤毛发生的分子调节机理，及其与胚胎发育和人类遗传性疾病的关系。研究内容涉及细胞骨架、中心体和纤毛等细胞结构，以及纤毛内物质运输、信号转导、基因表达、蛋白质相互作用等生物过程。本实验室的研究工作不仅对于了解中心体与纤毛这两种细胞器的生物学功能具有重要的科学价值，而且对于相关人类遗传性疾病的早期诊断与治疗具有重要的临床意义。
获得荣誉：
2023，国家人社部海外博士后引才专项
2022，山东省优秀青年科学基金（海外）
2022，泰山学者青年专家
2014，中国科学院院长特别奖
承担项目：
1. 纤毛发生与功能。2024.01-2026.12。国家人社部海外博士后引才专项。负责人。60万元。在研。
2. 纤毛蛋白CFAP97在初级纤毛和运动纤毛中的功能及分子机理。2023.01-2026.12。国家自然科学基金面上项目。负责人。54万元。在研。
3. 纤毛发生与功能。2022.04-2025.03。山东省优秀青年科学基金（海外）项目。负责人。60万元。已结题。
4. 多纤毛细胞deuterosome的产生机制。2016.01-2018.12。国家自然科学基金青年项目。负责人。22万元。已结题。
代表论著：
1. Lyu Q. *, Li Q. *, Li J. *, Luo J., Liu C., Nai S., Liu H., Zhu X., Song T. #, Liu M. #, and Zhao H. # (2026). Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia. eLife, 15: RP110601. doi: 10.7554/eLife.110601.1.
2. Li Q. *, Zi X. *, Lu Y., Yin H., Lyu Q., Han J., Shen H., Meng X., Nai S., Zhou J. #, Zhao H. #, and Song T. # (2026). Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice. J Mol Cell Biol, (Accepted).
3. Chen Q. *, Ma S. *, Liu H. *, Liu J., Li Q., Lyu Q., Yin H., Zhao J., Nai S., Song T., Liu H., Zhou J., Yan X., Zhu X. #, and Zhao H. # (2025). JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution. EMBO Rep, 10. doi: 10.1038/s44319-025-00671-7.
4. Lyu Q., Wang Y., Zhou J., Zhao H. #, Zhong T. #, and Li Q. # (2025). Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation. J Mol Cell Biol, 10: mjaf054. doi: 10.1093/jmcb/mjaf054.
5. Song T. *, Li Q. *, Lyu Q.*, Zhao J. *, Zi X., Ma S., Luo J., Li S., Nai S., Liu H., Zhu X., Li T., Zhou J. #, and Zhao H. # (2025). EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility. Proc Natl Acad Sci USA, 122 (41): e2510243122. doi: 10.1073/pnas.2510243122.
6. Lu Y. *, Zi X. *, Lyu Q. *, Li Q., Yin H., Wang Y., Chen Q., Kang B., Nai S., Zhou J., Zhao H. #, and Song T. # (2025). Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice. J Mol Cell Biol, 17(5): mjaf022. doi: 10.1093/jmcb/mjaf022.
7. Nai S. *, Zheng Y. *, Liu X., and Zhao H. # (2025). The new Nexin-Dynein regulatory complex component CCDC153 is dispensable for ciliary motility and fertility in mice. Cytoskeleton (Hoboken). doi: 10.1002/cm.70053.
8. Wang D., Li Q., Yu Z., Zhao J., Hu M., Geng S., Liu X., Zhao S., Song T., Liu M., Li D., Zhao H. #, and Zhou J. # (2025). FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis. J Cell Biol, 224(10): e202412224. doi: 10.1083/jcb.202412224.
9. Song D. *, Li Q. *, Sun Y. *, Zhao H. #, and Song T. # (2025). The cilia-associated protein CCDC89 is dispensable for male fertility in mice. Cytoskeleton (Hoboken). doi: 10.1002/cm.70057.
10. Song T. *, Zhou P. *, Zhang F. *, Liu C. *, Han X., Yue Y., Hu M., Yan S., Li Q., Liu M., Zhou J. #, and Zhao H. # (2025). USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation. J Genet Genomics, 53(2): 256-268. doi: 10.1016/j.jgg.2025.06.006.
11. Wang W., Shan Y., Liu R., Li D., Zhou J., Lu Q. #, and Zhao H. # (2025). Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis. J Clin Lab Anal, 39(9): e70000. doi: 10.1002/jcla.70000.
12. Zi X. *, Li Q. *, Lu Y., Lyu Q., Guo H., Meng X., Zhou J. #, and Zhao H. # (2024). CCDC181 is required for proper spermiogenesis in mice. J Genet Genomics, 51(11): 1327-1330. doi: 10.1016/j.jgg.2024.07.010.
13. Chen Q. *, Zhao H. *, Pan X., Fang C., Qiu B., Guo J., Yan X. #, and Zhu X. # (2024). A polarized multicomponent foundation upholds ciliary central microtubules. J Mol Cell Biol, 16(8): mjae031. doi: 10.1093/jmcb/mjae031.
14. Li T., Liu M., Yu F., Yang S., Bu W., Liu K., Yang J., Ni H., Yang M., Yin H., Hong R., Li D., Zhao H. #, and Zhou J. # (2024). Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms. J Mol Cell Biol, 16(1): mjad079. doi: 10.1093/jmcb/mjad079.
15. Lyu Q. *, Li Q. *, Zhou J. #, and Zhao H. # (2024). Formation and function of multiciliated cells. J Cell Biol, 223(1): e202307150. doi: 10.1083/jcb.202307150.
16. Zhao H. #, Li Q., and Zhou J. # (2023). Ciliary ectosomes: critical microvesicle packets transmitted from the cell tower. Sci Bull (Beijing), 68(22): 2674-2677. doi: 10.1016/j.scib.2023.09.027.
17. Tian X. *, Zhao H. *, and Zhou J. # (2023). Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond. eLife, 12: e87623. doi: 10.7554/eLife.8762.
18. Zhao H., Khan Z., and Westlake C. # (2022). Ciliogenesis membrane dynamics and organization. Semin Cell Dev Biol, 15: 133:20-31. doi: 10.1016/j.semcdb.2022.03.021.
19. Song T. *, Yang Y. *, Zhou P., Ran J., Zhang L., Wu X., Xie W., Zhong T., Liu H., Liu M., Li D., Zhao H. #, and Zhou J. # (2022). ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep, 23(5): e54090. doi: 10.15252/embr.202154090.
20. Zhao H. *, Sun J. *, Insinna C., Lu Q., Wang Z., Nagashima K., Stauffer J., Andresson T., Specht S., Perera S., Daar I. #, and Westlake C. # (2022). Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery. EMBO Rep, 23(4): e52775. doi: 10.15252/embr.202152775.
21. Zhao H. *, Chen Q. *, Li F., Cui L., Xie L., Huang Q., Liang X., Zhou J., Yan X. #, and Zhu X. # (2021). Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly. Nat Commun, 12(1): 1273. doi: 10.1038/s41467-021-21506-8.
22. Zhao H. *, Yang S. *, Chen Q., Duan X., Li G., Huang Q., Zhu X. #, and Yan X. # (2020). Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis. J Cell Sci, 133(13): jcs241836. doi: 10.1242/jcs.241836.
23. Zhao H. *, Chen Q. *, Fang C., Huang Q., Zhou J., Yan X. #, and Zhu X. # (2019). Parental centrioles are dispensable for deuterosome formation and function during basal body amplification. EMBO Rep, 20(4): e46735. doi: 10.15252/embr.201846735.
24. Zhao H., Zhu L., Zhu Y., Cao J., Li S., Huang Q., Xu T., Huang X., Yan X. #, and Zhu X. # (2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol, 15(12): 1434-44. doi: 10.1038/ncb2880.
